Venice, a city renowned for its picturesque waterways and rich history, is a quintessential vacation destination. When booking an apartment in Venice, consider a location near main attractions such as St. Mark’s Square and the Rialto Bridge for easy access. However, living like a local might lead you to quieter neighborhoods like Cannaregio or Dorsoduro.

Ensure the apartment has modern necessities like Wi-Fi, a well-equipped kitchen, and air conditioning for the warmer months. Staying in an apartment affords you the flexibility to prepare your own meals, a great way to sample local markets and save money on dining out.

Lastly, familiarize yourself with the public transportation system, particularly the waterbus lines (Vaporettos), as they're essential for getting around the city. Some apartments offer complimentary passes, a worthwhile perk. Additionally, always respect the apartment and its surroundings, as Venice's charm lies in its pristine preservation over centuries. 

Remember, vacationing is all about immersing yourself in the local culture and creating unforgettable memories. A Venice apartment provides an intimate glimpse into authentic Venetian life. Plan wisely to make the most of your stay.